Use Cases and Deployment Scope
Scaling is a huge issue in Neo4j. Clusters are supposed to allow horizontal scaling and they say they support billions of nodes, but in fact, a database with ~600 mil nodes and 1.5TB in size is barely manageable. Backups slow, count() times out, server restart will take hours (!!!!). And 2GB hard transaction limit is another hard candy of a clustered mode, requiring to use things like apoc.iterate for long updates, making them impossible to rollback in case something goes wrong (apoc.iterate commits results on the go).
So - if you need scaling, think twice.