Nodexus

The NX One, developed by Nodexus Inc., is an automated multi-functional platform designed to facilitate the analysis, sorting, and dispensing of single cells. According to the vendor, it offers a versatile solution for various single-cell workflows, including cell line development, CRISPR workflows, cell and gene therapy, single-cell genomics, stem cell and rare cell isolation, and the sorting and characterization of cell clusters such as spheroids and organoids. This platform is intended for use by research laboratories and academic institutions of various sizes and is targeted towards research scientists, biologists, geneticists, biotechnology companies, and pharmaceutical companies.

Key Features

Flexible Affordable Single-Cell Sorting: The NX One is a benchtop system that, according to the vendor, offers gentle sorting and dispensing of single cells in one easy-to-use platform. It provides high viability for precious samples with 20x lower pressure than traditional sorters, ensuring maximum cell survival. The system ensures a contamination-free workflow with low-cost microfluidic cartridges that provide aseptic sample processing, minimal biohazard waste generation, and no aerosols.

High viability for your most precious samples: The NX One, as claimed by the vendor, utilizes 20x lower pressure than traditional sorters to ensure high viability for precious samples. It offers a contamination-free workflow with low-cost microfluidic cartridges that provide aseptic sample processing and minimal biohazard waste generation. The system eliminates aerosols, enhancing sample safety. With gentle cell sorting at less than 2 psi, the NX One aims to maximize the viability of sorted and recovered samples. It is suitable for sorting heterogeneous or homogeneous samples of various cell sizes, including spheroids and organoids.

Walk-up usability: The NX One is designed for easy setup and operation, allowing any untrained researcher to begin sorting in under 30 minutes, according to the vendor. It features a user-friendly wireless interface that simplifies the sorting process and enables real-time monitoring of runs and visualization of data. The system provides intuitive software that facilitates the monitoring and control of sorting and dispensing operations. It offers a front-facing fluidics compartment for internal storage, ensuring easy access and efficient workflow. The NX One allows for the dispensing of sorted cells into microplates or collection tubes, providing flexibility in downstream applications.

Laser and rugged optics for particle sizing and fluorescence measurements: The NX One is equipped with laser and rugged optics that, according to the vendor, enable accurate particle sizing and fluorescence measurements. It ensures precise analysis of single cells, allowing for efficient sorting based on specific characteristics. The system supports a wide range of fluorescence measurements, enabling the detection and isolation of target cell populations. It provides reliable and consistent results for various applications, such as cell line development and CRISPR workflows. The NX One's optical system is designed to handle the complexities of single-cell analysis with robust performance.

Microfluidic cartridge for gentle, contamination-free sorting and dispensing: The NX One utilizes a microfluidic cartridge for gentle and contamination-free sorting and dispensing of single cells, as claimed by the vendor. The cartridge design eliminates the need for external tubing, simplifying the workflow and reducing the risk of contamination. It ensures aseptic sample processing, minimizing biohazard waste generation and maintaining sample integrity. The microfluidic cartridge allows for precise control of fluid flow, enabling efficient sorting and dispensing of cells. It aims to provide high viability of sorted and recovered samples, preserving the quality of precious cells.

Elevate the potential of your single cells: The NX One, according to the vendor, offers versatile functionality that can enhance various single-cell workflows. It is suitable for single-cell dispensing in cell line development, enabling clonal expansion and isolation of high-producing recombinant cell lines. The system facilitates the selection of GFP+ population for CRISPR workflows, optimizing gene editing efficiency. It allows for the enrichment of target cell populations into microplates, streamlining downstream applications. The NX One can be used for dispensing reagents/media for sample prep and processing, enhancing workflow efficiency. It supports phenotype characterization of antibody-stained cells, enabling detailed analysis and characterization of cell populations.