Clireo

Clireo, developed by Carl Zeiss Microscopy Software Center Rostock GmbH, is a scientific image analysis software designed to provide advanced tools and functionalities for analyzing and processing microscopy data. According to the vendor, Clireo caters to a wide range of professionals and industries, including biomedical researchers, cell biologists, microscopists, life science researchers, pharmaceutical companies, and academic institutions. With its versatile features and user-friendly interface, Clireo is positioned as a solution for businesses of all sizes.

Key Features

Flexible Seeded Region Growing: According to the vendor, Clireo offers a Seeded Region Growing Operation that allows users to segment whole cell bodies based on positive nuclear staining and separate close cells by choosing different channels for seeding and growing.

New Watershed Operation: Clireo includes a Watershed Operation that can split objects of any shape, which the vendor claims makes it easy to detect non-roundish cells and combine with other segmenters for seeding or objects added via Virtual Reality.

Easy Splitting within the Pipeline: Clireo provides a Splitting Operation that can automatically split segmentation objects in a pipeline run, simplifying the process and potentially enhancing segmentation workflows' efficiency, according to the vendor.

Membrane-based Segmentation: Clireo offers a Membrane-based Segmentation feature that allows users to define cell boundaries based on membrane-localized contrast. The vendor states that it includes algorithms for enhancing membranes in 3D and a segmentation operator designed specifically for segmenting cells in 3D.

Colocalization: According to the vendor, Clireo includes a Colocalization operator that enables users to identify relationships between objects in a one-to-any relationship, which is useful for finding colocalized objects and measuring their relationships.

Customizable Magic Wand: Clireo provides a Customizable Magic Wand tool for manual segmentation tasks, allowing users to define regions of interest and segment objects based on brightness, darkness, or highlighted areas within a range, according to the vendor.

Color Settings: According to the vendor, Clireo offers comprehensive color handling features, allowing users to customize color settings for image visualization, including min and max values, gamma adjustment, outlier exclusion, and custom color gradients.

Dynamics and Tracking: Clireo provides a Tracking and Lineage module for analyzing object movement over time in 2D or 3D multichannel image sets. The vendor claims it supports manual track creation, proof editing, and virtual reality tracking for accurate analysis.

Segmentation of Presynaptic Terminals and Mitochondria: Clireo allows users to segment and outline presynaptic terminals and mitochondria in multidimensional microscopy images. The vendor states that it provides a web browser interface for collaborative segmentation, and users can associate objects with local copies of image datasets.