1. If a headless CMS is needed. 2. Need the cms UI to be clean. 3. There is a need for customization options in the UI and API as well. 4. Expertise in javascript and need cms with node js backend. 5. Want auth APIs pre-made. 6. Easy to customize the backend as well. 7. The user interface can be fully customizable.
TYPO3 is great if you need to connect some systems in company to work together: like ecommerce + CRM + ERP + MRP and build an Extranet for partners/dealers where they can order your products, see particular BOM (bill of material), paid/unpaid invoices and use email marketing on top of it. You can do it but keep in mind that you will need a dedicated hosting, well organized admin(s) and some handwritten code. For simple blog TYPO3 is also a good choose, but WP would be better I think.
compared do Wordpress - far less community support
when you run a simple blog - it is simple as piece of cake. But if it is a large news site, with many user roles, extensions and permissions - it may be hard to find an admin that will organize and keep that stuff working.
server resources: so you want performance and speed with all that modules enabled? make sure that you have dedicated server in most cases. WP works much better here.
