The most appropriate scenarios to implement email security is in companies that want to protect the use of electronic mail since it is one of the security breaches that are currently used to perform any type of attack. Very effective integration with Office 365 and it is highly recommended to add the functionality of advanced malware protection
Cisco Cloudlock is a good fit for my organization consisting of 150 end users. While we have a small office product that can expand to cover any size organization, I would assume the overhead to monitor would increase. While my organization's business is in real estate, I would highly recommend this for all businesses that handle sensitive and private data. Being able to monitor our cloud infrastructure has allowed our security team to be more flexible in allowing approved users access as well.
Cisco TAC support is very good since they have engineers available 24 hours a day, 365 days a year. Important to mention that you must have the support of the solution enabled to be able to receive a response from TAC and that we can be taken care of. The only drawback may be that they will not be able to see settings of the email provider you use.
They are very quick to respond and go the extra mile to help address our issues. That said, we've only needed them at the early stages of implementation for support help and occasionally when we want to do a full re-scan of our site. They are very flexible in working with us on the timing of such scans.
Cisco was at least better than or equal to the others but within our budget. It provided all of the services of anti-spam, content filtering, anti-virus, DLP, encrypted email service, scalability, and more than the others. Cisco name and reputation were also key in our decision.
Amazon Macie is limited to an AWS environment and fulfills some of the same functions that CloudLock does in SaaS products. Both are very valuable tools, so the decision is not really which to use, but whether to use both for their respective environments. In general I feel CloudLock is a more powerful tool because it connects to Microsoft 365, which is more business critical for our organization, but that really is a personal call.