Cisco Cloudlock is a good fit for my organization consisting of 150 end users. While we have a small office product that can expand to cover any size organization, I would assume the overhead to monitor would increase. While my organization's business is in real estate, I would highly recommend this for all businesses that handle sensitive and private data. Being able to monitor our cloud infrastructure has allowed our security team to be more flexible in allowing approved users access as well.
FortiMail is useful for small businesses and large companies. If you are looking to filter inbound and outbound email, then it will do an effective job of keeping your network safe. The virus, malware, spam definitions are updated on a daily basis and will help any company that is looking to eliminate spam and malware.
They are very quick to respond and go the extra mile to help address our issues. That said, we've only needed them at the early stages of implementation for support help and occasionally when we want to do a full re-scan of our site. They are very flexible in working with us on the timing of such scans.
Any time I've had to use the support, it has been great! They always will recommend certain options, as well as explain what they do and why they are there. The support always gets back to me the same day, and are always pleasant to deal with. I never hesitate to call.
Amazon Macie is limited to an AWS environment and fulfills some of the same functions that CloudLock does in SaaS products. Both are very valuable tools, so the decision is not really which to use, but whether to use both for their respective environments. In general I feel CloudLock is a more powerful tool because it connects to Microsoft 365, which is more business critical for our organization, but that really is a personal call.
I have used Barracuda Email Security in the past and FortiMail is just as effective. The interface is easy to use, and the configuration is straightforward in setting it up to work with Microsoft Exchange. Spam detection is effective, as well as malware/viruses and phishing attempts. Overall it is a great service.