1) Securing your back-end APIs - If you have a legacy back-end web service that has a basic authentication scheme, you can add some additional security by placing APIM in front, and requiring subscription keys. Leverage your existing firewall to ensure only your APIM instance can communicate with your back-end API, and you've basically added a layer of protection.
2) Lift and shift - there are always going to be clients that don't want to update their clients to use a newer API; in some cases you can make a newer API look like an older one by implementing some complex policies in APIM. You can also do the opposite, making older APIs look new, such as making an XML back-end accept both JSON and XML.
3) Centralizing your APIs - if you've acquired another company and want to make their API set look as if it's a part of the larger whole, APIM is an easy way to provide a consistent front-end interface for developers.
BizTalk is well suited as middleware. Where you wish to translate an input file into an output file and send it to some endpoint. In our case, we used it to convert and send files to SAP. In many ways, it very flexible, and you can do almost anything you want with it. In many ways, it's a better solution than your SAP XI or PI as middleware, since it's much less expensive, and allows you do interface with non-SAP systems.
It is very user friendly. Users can change rules during run time and change workflow.
Huge capacity for queueing messages. It supports all types of adapters like Oracle, Salesforce, SMTP, FTP, etc. Also users can built custom adaptors.
If users want to dynamically deploy their solution without any downtime, this is a perfect solution. BizTalk will be a good fit, especially for public-facing websites.
Well-proven in the market. I used it when developing a website for Virgin Trains, catering more than 800K user requests per day.
Lack of robustness is a bit of an issue. Several other providers offer more options and capabilities, but then, they are lacking in interface ease.
As with anything Azure, pricing is really hard to stay on top of. I always find that you really don’t know what you’re paying for until you get the bill. Having an excellent Azure Administrator can help resolve that.
Integrating with app services outside of Azure can be a challenge, or at least much more challenging than just using Azure App Services.
BizTalk Server has been supported for more than 15 years. It is well proven in the market. Microsoft has provided excellent support with technical issues.
BizTalk was selected here mainly because it is easy to integrate to a .NET application (most of them are Web Service, WCF SOAP, WCF REST and Web API) and many backend databases are Microsoft SQL Server. Another benefit is that the monitoring job is easy to set up and centralize with other .NET application monitoring jobs.
A positive impact has been the quicker turnaround time of a part request and that part showing up in SAP using Biztalk as middleware.
A somewhat negative impact has been the somewhat insufficient error logging/message capture settings that Biztalk provide. This has caused occasional delays when attempted to create parts for the business.
A somewhat negative impact has been the need to have a specialized developer who understands Biztalk to troubleshoot issues with the Biztalk and SAP interaction when creating parts, and when adding new fields to the parts.