I actually think it's almost exactly the same as VirtualBox. VirtualBox I used for hosting a Linux distribution, and I think that there are inherently more problems to configuring a Linux distribution than there are to a Windows virtual machine, so mostly my issues were due to that. Coming from VirtualBox, I was able to set up VMWare perfectly to my specifications. VMWare does have better out of the box file sharing between operating systems though.
Emulating Windows is all that I use it for, and it does that seamlessly. Obviously there are slightly different functionalities between operating systems, but it is very intuitive. The setup can be done by people that have never set up a virtual machine before quite easily. I think there was one coworker complaining about its lack of multi-screen functionality though.