Patriot is well suited for an office with a small staff without complicated tax issues to manage. My office had 2 employees: one full-time and one part-time. There were no 1099's issued, and no special tax exemptions or other special tax situations for employees. The owner was a sole proprietor, so she was not paid as an employee through Patriot. It was easy to quickly run simple payroll tasks on a bi-weekly basis in my situation.
However, I believe a more complex situation with more employees would still be suitable for this software if there was an employee dedicated to performing payroll and human resources tasks. Information must be manually entered each payroll period and submitted before 8pm to process at the scheduled pay date, so if there was not a dedicated employee for the task, it would be easy to end up paying employees a business-day late.
I know that Patriot offers add-on services for human resource tasks, such as time sheets and tools to manage sick days, benefits, and record employee attendance. I did not require these extra services, but I like that Patriot offers services a la carte so that there is no need to pay for tools you do not need.