Zix is a best practices solution that anyone with secure data should be using

From an end-user, sender perspective, there's literally nothing you have to do to use Zix. Just send your e-mail like you always would. If it has sensitive data, Zix will send it through its secure network encrypted. If you do need to send something without information that would trigger a rule, you can set up a subject keyword or flag an e-mail as "sensitive", and it'll encrypt that, too. For recipients, if they do not have Zix, it can be a little awkward, but it's still very functional. They log into a portal, read their message/documents, and can use the portal to reply as well, keeping the information secure in both directions.

Zix is great for anyone who has to send and receive sensitive data like financial or medical records and guarantee their security. If your organization needs to follow regulations like SOX, HIPAA, or something similar, and you have an IT team or managed service provider that can maintain it, Zix is a great solution. I also think it's best suited to an on-premises e-mail solution because of how it integrates with mail flow for scanning, although I believe they have a version for Office 365. If instead, your organization only occasionally sends things secured or does not have the IT support staff to maintain it, it might be worth looking for a different solution. For the most part, once it's installed, it doesn't require much hands-on, but there are enough occasions that without expertise it could remain daunting.

Zix is very good about response times and information. They even proactively e-mail us about known issues. I have never had an issue go unresolved, and the support team tends to answer quickly unless it's a strange, complicated request. The only time that happened was doing a search through logs, and that was entirely on me and my unfamiliarity with their flavor of Linux.